Nestled in the Blue Ridge Mountains, Asheville is a city with a hometown feel. Find a country cabin or bed & breakfast for a reasonable price (or even less) and then take off for downtown. Wander through the plethora of shops and galleries before stopping in Jack of the Woods brewpub for a cold one. Be sure to grab a six-pack of Highland brew from the local grocery before heading back to your abode. Put your feet up, have a beer and enjoy the cool mountain air. There is a nice craft beer/foodie scene to enjoy as well.